Filaggrin Antibody | V3841-100UG

Filaggrin Antibody | V3841-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Format: Purified

Clone: FLG/1945

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: IHC-P

Buffer: N/A

Limitation: This Filaggrin antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: Filaggrin (FLG) is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple Filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional Filaggrin molecules. Active Filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.

Immunogen: A portion of amino acids 998-1104 from the human protein were used as the immunogen for this Filaggrin antibody.

Storage: Store the Filaggrin antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).