FGFR1 (V561M), GST-tag | 40209

FGFR1 (V561M), GST-tag | 40209 | Gentaur US, UK & Europe Disrtribition

Category: Kinase/Receptor Tyrosine

Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling

Background: FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family that constitute a family of four membrane-spanning tyrosine kinases (FGFR1-4) which serve as high-affinity receptors for 17 growth factors (FGF1-17). The FGF Receptor family plays an important role in multiple biological processes, including mesoderm induction and patterning, cell growth and migration, organ formation and bone growth (1). FGFR1 is alternatively spliced generating multiple splice variants that are differentially expressed during embryo development and in the adult body (2).

Description: Recombinant human FGFR1 (GenBank Accession No. NM_023110), a.a. 399-822, with valine to methionine mutation at a.a. 561 and N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.

Product Type: Protein

Shippement Condition: -80°C