Description
FcRL5/Firefly Luciferase RPMI 8226 Cell Line | 78378 | Gentaur US, UK & Europe Disrtribition
Category: Immunotherapy/Cell Line
Application: Use as target cells for anti-FcRL5 CAR T cells, anti-FcRL5 ADC, and bi-specific antibodies.
Background: FcRL5 is a single-pass type 1 membrane protein which contains 8 immunoglobulin-like C2-type domains. FcRL5 may be involved in B cell development and lymphomagenesis. Moreover, it is enriched in malignant plasma cells of patients diagnosed with multiple myeloma, and is an attractive target for antibody-drug conjugates (ADC) and anti-FcRL5 CAR T cells. RPMI 8226 cells are human B cells isolated from a plasmacytoma/myeloma patient.
Description: Recombinant RPMI 8226 cells constitutively expressing firefly (Photinus pyralis) luciferase (BPS Bioscience #79834) have also been engineered to constitutively express the full length human FcRL5 (Fc Receptor Like 5, also known as CD307, ref. seq. NM_031281).
Product Type: Cell Line
Shippement Condition: -80°C
