Description
FcGRIIIA (CD16a) Lentivirus | 79876 | Gentaur US, UK & Europe Disrtribition
Category: Cell Line/Lentiviruses
Application: 1. Transient expression of FcGRIIIA in target cells.
2. Generation of stable cell line expressing FcGRIIIA with Geneticin (G418) selection.
Background: N/A
Description: Fc Gamma Receptor IIIa (FcGRIIIA; FcγRIIIA), also known as CD16a, is a low/intermediate affinity receptor for polyvalent immune-complexed IgG. It is involved in phagocytosis, antibody-dependent cytotoxicity and clearance of immune complexes. The human FcγRIIIa displays a dimorphism in the position of residue 158. One allele (V158) encodes a higher Fc affinity receptor variant with a valine at amino acid residue 158, and the other (F158) encodes a lower Fc affinity receptor variant having a phenylalanine at amino acid residue 158.
The FcGRIIIA Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types mammalian cells, including primary and non-dividing cells. The particles contain a FcGRIIIA gene (NM_001127593.1; high affinity V158 variant) driven by a CMV promoter.
Product Type: Lentivirus
Shippement Condition: -80°C
