FcGR2B - CHO K1 Recombinant Cell Line | 79511

FcGR2B - CHO K1 Recombinant Cell Line | 79511 | Gentaur US, UK & Europe Disrtribition

Category: Immunotherapy/Cell Line

Application: • Screen for activators or inhibitors of antibody-mediated signaling by coculturing with the FcGR2B CHO K1 cells. • Characterize the agonist activity of antibodies by crosslinking to the FcGR2B receptor.

Background: Fc Gamma Receptor 2B (FcGR2B, FcγRIIB), also known as CD32B, is a "low affinity" receptor for Immunoglobulin G (IgG). FcGR2B is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Mutations in the gene encoding FcGR2B have been linked to systemic lupus erythematosus (SLE). FcGR2B is the predominant Fc receptor present on B cells, and high expression of FcγRIIB negatively regulates mAb-mediated immunotherapy. Therefore, FcGR2B is an important immunotherapy target, both directly for B-cell malignancies and in combination with clinically relevant therapeutic mAbs to overcome FcGR2B-mediated resistance.

Description: Recombinant FcGR2B-CHO K1 cell line stably expressing full length human FcGR2B (isoform 1, GenBank Accession Number NM_004001.4). Crosslinking of antibodies bound to target by FcGR-expression cells can promote receptor clustering and increase downstream signaling. FcGR2B crosslinking is important for anti-TNFR receptor antibodies.

Product Type: Cell line

Shippement Condition: -80°C