Description
FBXW7 Antibody | F53267-0.08ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: WB, ELISA
Buffer: N/A
Limitation: This FBXW7 antibody is available for research use only.
Purity: Antigen affinity
Description: Substrate recognition component of an SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. Identified substrates include cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. [UniProt]
Immunogen: This FBXW7 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 177-208 amino acids from the N-terminal region of human FBXW7.
Storage: Aliquot the FBXW7 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
