Description
FAT10 Antibody | R31346 | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: WB, IHC-P
Buffer: N/A
Limitation: This FAT10 antibody is available for research use only.
Purity: Antigen affinity
Description: Ubiquitin D, Diubiquitin or FAT10 (HLA-F-adjacent transcript 10), is a protein that in humans is encoded by the UBD gene. It is a ubiquitin-like protein modifier that can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome in a NUB1L-dependent manner. This gene may be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. It may be involved in the formation of aggresomes when proteasome is saturated or impaired. FAT10 mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN). It may also function as a survival factor.
Immunogen: An amino acid sequence from the N-terminus of human HLA-F-adjacent transcript 10 (YDSVKKIKEHVRSK) was used as the immunogen for this FAT10 antibody.
Storage: After reconstitution, the FAT10 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.
