FAS Antibody (phospho-Y291) | F48476-0.08ML

FAS Antibody (phospho-Y291) | F48476-0.08ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS pH 7.4 with 0.09% sodium azide

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human

Application: DB, ELISA

Buffer: N/A

Limitation: This phospho-FAS antibody is available for research use only.

Purity: Antigen affinity

Description: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). [UniProt]

Immunogen: This phospho-FAS antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pY291 of human FAS.

Storage: Aliquot the phospho-FAS antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.