Fas Antibody / CD95 | V2633-20UG

(No reviews yet) Write a Review
SKU:
800-V2633-20UG
Size:
20 ug
€649.00
Frequently bought together:

Description

Fas Antibody / CD95 | V2633-20UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Format: Purified

Clone: B-R18

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: Functional studies, FACS, IF, IHC-F

Buffer: N/A

Limitation: This Fas antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: mAb B-R18 specifically recognizes CD95, also known as Fas, a transmembrane glycoprotein with a MW of 40-45kDa, containing 8kDa of N-glycosidic-linked polysaccharide. It is a receptor for TNFSF6/FASLG, a member of the nerve growth factor receptor/tumor necrosis factor superfamily, mediating receptor-triggered apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation, which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). CD95 antigen is expressed on the surface of various cell types, preferentially on the CD45RAlow CD45ROhigh subset of memory T lymphocytes.

Immunogen: Recombinant human protein was used as the immunogen for the Fas antibody.

Storage: Store the Fas antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).

View AllClose