Description
FALZ (BPTF), GST-tag | 31134 | Gentaur US, UK & Europe Disrtribition
Category: Bromodomain/Protein
Application: Useful for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling.
Background: FALZ is a bromodomain-containing protein that is the histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on Lys4 (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. High levels of FALZ were detected in fetal brain and in patients with neurodegenerative diseases.
Description: Human Fetal Alzheimer Antigen (FALZ), also known as Fetal Alz-50 Clone 1 Protein or bromodomain PHD finger transcription factor (BPTF), GenBank Accession No. NM_182641, a.a. 2791-2911 corresponding to single bromodomain, with N-terminal GST-tag, MW=41 kDa, expressed in an E. coli cell expression system.
Product Type: Protein
Shippement Condition: dry ice
