Description
Exportin 2 antibody / CSE1L | F54382-0.4ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human, Mouse
Application: IHC-P, IF, WB
Buffer: N/A
Limitation: This Exportin 2 antibody is available for research use only.
Purity: SAS precipitation
Description: Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. CSE1L binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, CSE1L may play a role both in apoptosis and in cell proliferation.
Immunogen: A portion of amino acids 55-84 from the human protein was used as the immunogen for the Exportin 2 antibody.
Storage: Aliquot the Exportin 2 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
