Description
Estrogen Receptor α(ER) Monoclonal Antibody | PA6541 | Gentaur US, UK & Europe Disrtribition
Clone : YN00806m
Reactivity : Human
Application : IHC-P
Host : Mouse
Category : RTU for IHC
Concentration : 100μg/mL for the RTU antibody, 1mg/mL for the concentrated antibody
Buffer : TBS with 0.1% Proclin300, PH7.4
Backgound : Estrogen receptor (ER) is a steroid receptor of nuclear receptor superfamily, which consists of 553 aa. ER have three domains: the central domain of DNA binding, the hormone binding domain of C-terminal and the transcriptional activation domain of N-terminal. ER is involved in the regulation of female sex hormones, mainly mediating the growth, differentiation and other functions of 17 (E2) on several target tissues . ER α is expressed in the nucleus of epithelial cells of normal breast and endometrium, and also in breast cancer. Immunohistochemistry analysis showed that the overall survival rate of steroid positive prediction is good. RE α can also be used as a tumor marker combined with anti-progesterone receptor antibody.
