Description
Estrogen Receptor Antibody (alpha) | R31605 | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: WB, IHC-P
Buffer: N/A
Limitation: This Estrogen Receptor antibody is available for research use only.
Purity: Antigen affinity
Description: Estrogen receptor alpha (ERa), also known as NR3A1, is one of two main types of estrogen receptor, a nuclear protein that is activated by the sex hormone estrogen. ERs are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. In humans, ERa is encoded by the gene ESR1. It is mapped to 6q25.1. This gene is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2/beta. Estrogen and its receptors are essential for sexual development and reproductive function, it also play a role in other tissues such as bone.
Immunogen: Human ERa partial recombinant protein (AA 425-595) was used as the immunogen for this Estrogen Receptor antibody.
Storage: After reconstitution, the Estrogen Receptor antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.
