Estrogen Receptor alpha Antibody | V9393SAF-100UG

Estrogen Receptor alpha Antibody | V9393SAF-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 1 mg/ml in 1X PBS; BSA free, sodium azide free

Format: Purified

Clone: ESR1/6983R

Host: Rabbit

Clonality: Recombinant Rabbit Monoclonal

Isotype: Rabbit IgG, kappa

Species Reactivity: Human

Application: WB, IHC-P

Application Details: Western blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml

Application Note: Optimal dilution of the recombinant ESR1 antibody should be determined by the researcher.

Purity: Protein A/G affinity

Description: Estrogen receptor (ER) belongs to the steroid receptor superfamily of nuclear receptors. It is a protein with 553 amino acids. The receptor molecule has three domains, i.e. the central DNA-binding domain, the hormone-binding domain at the C-terminal, and the transcription-activating domain at the N-terminal. ER mediates regulatory functions of female sex steroids, mainly 17 (E2), on growth, differentiation and function in several target tissues, including female and male reproductive tract, mammary gland, and skeletal and cardiovascular systems.Studies have shown ER can be used as a tumor marker, preferentially in combination with an antibody to progesterone receptor, e.g., in the classification of adenocarcinomas.

Immunogen: A portion of amino acids 495-595 was used as the immunogen for the recombinant ESR1 antibody.

Storage: Aliquot the recombinant ESR1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.

Localization: Nucleus