Estrogen Receptor alpha Antibody | V9392-100UG

Estrogen Receptor alpha Antibody | V9392-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: ESR1/4039R

Host: Rabbit

Clonality: Recombinant Rabbit Monoclonal

Isotype: Rabbit IgG, kappa

Species Reactivity: Human

Application: IHC-P

Application Details: Immunohistochemistry (FFPE): 1-2ug/ml

Application Note: Optimal dilution of the recombinant ERa antibody should be determined by the researcher.

Purity: Protein A/G affinity

Description: The ER gene consists of more than 140kb of genomic DNA divided into 8 exons, being translated into a protein with six functionally discrete domains, labeled A through F. This antibody strongly stains the nucleus of epithelial cells in breast carcinomas. The ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to antiestrogen (e.g. tamoxifen) therapy.

Immunogen: A recombinant protein fragment from the C-terminal region was used as the immunogen for the recombinant ERa antibody.

Storage: Aliquot the recombinant ERa antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.

Localization: Nucleus