Description
Estrogen Receptor alpha Antibody | V4010-100UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Format: Purified
Clone: rESR1/7162
Host: Mouse
Clonality: Recombinant Mouse Monoclonal
Isotype: Mouse IgG1, kappa
Species Reactivity: Human
Application: IHC-P
Application Details: Immunohistochemistry (FFPE): 1-2ug/ml
Application Note: Optimal dilution of the recombinant Estrogen Receptor alpha antibody should be determined by the researcher.
Purity: Protein A/G affinity
Description: Recognizes a protein of 67kDa, which is identified as estrogen receptor (ER) alpha. The ER gene consists of more than 140kb of genomic DNA divided into 8 exons, being translated into a protein with six functionally discrete domains, labeled A through F. This antibody strongly stains the nucleus of epithelial cells in breast carcinomas. The ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to antiestrogen (e.g. tamoxifen) therapy.
Immunogen: A recombinant fragment corresponding to the C-terminus from the human ER alpha was used as the immunogen for the recombinant Estrogen Receptor alpha antibody.
Storage: Aliquot the recombinant Estrogen Receptor alpha antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
Localization: N/A
