ERCC2 Antibody | F53151-0.4ML

ERCC2 Antibody | F53151-0.4ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human

Application: WB, ELISA

Buffer: N/A

Limitation: This ERCC2 antibody is available for research use only.

Purity: Antigen affinity

Description: ATP-dependent 5'-3' DNA helicase, component of the core- TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.

Immunogen: This ERCC2 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 687-722 amino acids from the C-terminal region of human ERCC2.

Storage: Aliquot the ERCC2 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.