Description
EPHA4, GST-tag | 40193 | Gentaur US, UK & Europe Disrtribition
Category: Kinase/Receptor Tyrosine
Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Background: EPHA4 also known as EPH receptor A4, belongs to the ephrin receptor subfamily of protein-tyrosine kinases which have been implicated in mediating developmental events, particularly in the nervous system (1). The EPHA4 ligand ephrin-A3 is localized to the astrocytic processes that envelop the spine. Activation of EPHA4 by ephrin-A3 induces spinal retraction and reduces spine density and inhibits the interaction distorted spine shape and organization. EPHA4-null mice possess defects in the corticospinal tract and anterior commissure indicating a model in which an ephrin ligand on the axons senses EPHA4 on spinal cord cells surrounding the corticospinal tract (2).
Description: Human EPHA4 (Ephrin Receptor A4), also known as TYRO1, SEK, and HEK8, GenBank Accession No. NM_004438, a.a. 610-887, with N-terminal GST-tag, MW ~58 kDa, expressed in Sf9 insect cells via a baculovirus expression system.
Product Type: Protein
Shippement Condition: -80°C
