Description
EpCAM Antibody | V7934-0.5ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: Culture supernatant with 0.05% sodium azide
Format: Culture supernatant
Clone: Ber-EP4
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human
Application: IHC-P, FACS
Buffer: N/A
Limitation: This EpCAM antibody is available for research use only.
Purity: Unpurified high titer supernatant
Description: Recognizes a 40-43kDa transmembrane epithelial glycoprotein, identified as epithelial specific antigen (ESA), or epithelial cellular adhesion molecule (Ep-CAM). It is expressed on baso-lateral cell surface in most simple epithelia and a vast majority of carcinomas with the exception of adult squamous epithelium, hepatocytes and gastric epithelial cells. This antibody has been used to distinguish adenocarcinoma from pleural mesothelioma and hepatocellular carcinoma. It is also useful in distinguishing serous carcinomas of the ovary from mesothelioma. It has been reported that this epithelial antigen plays an important role as a tumor-cell marker in lymph nodes from patients with esophageal carcinoma otherwise classified as node-negative. Epithelial antigen has also been suggested as a discriminator between basal cell and baso-squamous carcinomas, and squamous cell carcinoma of the skin.
Immunogen: Human breast cancer MCF-7 cells were used as the immunogen for the EpCAM antibody.
Storage: Store the EpCAM antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
