EIF2A Antibody / EIF2S1 | V9225-20UG

EIF2A Antibody / EIF2S1 | V9225-20UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: PCRP-EIF2S1-1C11

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: FACS

Buffer: N/A

Limitation: This EIF2S1 antibody is available for research use only.

Purity: Protein A/G affinity

Description: The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. The eukaryotic initiation complex is composed of three subunits, designated eIF2a, eIF2band eIF2g (eukaryotic translation initiation factor 2 a, band g, respectively), all of which work in concert to form a ternary complex with GTP and tRNA in the early stages of protein synthesis. eIF2a, also known as EIF2S1 or EIF2, is a 315 amino acid subunit of the eukaryotic initiation complex that functions to bind tRNA to the 40S ribosomal subunit (in a GTP-dependent manner), thereby initiating translation. In addition, the phosphorylation state of eIF2a controls the rate of tRNA translation. When eIF2a is not phosphorylated, translation occurs at a normal rate. However, upon phosphorylation by one of several kinases, eIF2a is stabilized, thus preventing the GDP/GTP exchange reaction and slowing translation.

Immunogen: Recombinant full-length human EIF2S1/EIF2A protein was used as the immunogen for the EIF2S1 antibody.

Storage: Aliquot the EIF2S1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.