Description
EGFR (T790M L858R), DEL 746-750, GST-Tag | 79435 | Gentaur US, UK & Europe Disrtribition
Category: Kinase/Kinase Receptor Tyrosine
Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Background: EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival (1). Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms (2). Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation.
Description: Recombinant Human EGFR also known as ERBB, mENA, ERBB1, and HER1 with T790M and L858R mutations and 746-750 deletion. Genbank Accession NM_005228, a.a. 668-end, with an N-terminal GST-tag, expressed in Sf9 cells via a baculovirus expression system. MW = 105 kDa.
Product Type: Protein
Shippement Condition: -80°C
