EGF Receptor / EGFR Antibody | V8745-100UG

EGF Receptor / EGFR Antibody | V8745-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: GFR/4563R

Host: Rabbit

Clonality: Recombinant Rabbit Monoclonal

Isotype: Rabbit IgG

Species Reactivity: Human

Application: IHC-P

Application Details: Immunohistochemistry (FFPE): 1-2ug/ml for 30 minutes at RT

Application Note: Optimal dilution of the recombinant EGFR antibody should be determined by the researcher.

Purity: Protein A affinity chromatography

Description: This MAb recognizes a protein of 170kDa, identified as EGFR. EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.

Immunogen: A portion of amino acids 1050-1150 from the human protein was used as the immunogen for the recombinant EGFR antibody.

Storage: Store the recombinant EGFR antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).

Localization: Cytomembrane