Description
E2F1 Antibody | R30637 | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human, Mouse, Rat
Application: WB
Buffer: Lyophilized from 1X PBS with 2% Trehalose
Limitation: This E2F1 antibody is available for research use only.
Purity: Antigen affinity
Description: E2F1 is a member of the E2F family of transcription factors. The E2F family of transcription factors play a critical role in the transcription of certain genes required for cell cycle progression. E2F1, the first cloned member of this family, is regulated during the cell cycle at the mRNA level by changes in transcription of the gene and at the protein level by complex formation with proteins such as the retinoblastoma gene product(pRB), cyclin A and DP1. E2F1 can override a pRB-induced G1/S block and can behave as an oncogene in certain cells. The transcription factor can promote proliferation or apoptosis when activated, and is a key downstream target of the retinoblastoma tumor suppressor protein (pRB).
Immunogen: An amino acid sequence from the middle region of human E2F1 (VTCQDLRSIADPAEQ) was used as the immunogen for this E2F1 antibody (100% homologous in human, mouse and rat).
Storage: After reconstitution, the E2F1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.
