E-Cadherin Antibody / CDH1 | RQ5389

E-Cadherin Antibody / CDH1 | RQ5389 | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: Antibody in PBS with 0.02% sodium azide and 50% glycerol

Format: Purified

Clone: COH-3

Host Animal: Rabbit

Clonality: Rabbit Monoclonal

Species Reactivity: Human, Mouse, Rat

Application: IHC-P, WB

Buffer: N/A

Limitation: This E-Cadherin antibody is available for research use only.

Purity: Affinity purified

Description: The CDH1 gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. [RefSeq]

Immunogen: A synthetic peptide specific to human E-Cadherin / CDH1 was used as the immunogen for the E-Cadherin antibody.

Storage: Store the E-Cadherin antibody at -20 °C.