Description
Dystrophin Antibody | R30032 | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.5mg/ml with 1% BSA and 0.01% sodium azide if reconstituted with 0.2ml sterile 1XPBS
Format: Ascites
Clone: MANDYS8
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human, mouse, rat, rabbit
Application: WB, IHC-P
Buffer: N/A
Limitation: This Dystrophin antibody is available for research use only.
Purity: Ascites
Description: Dystrophin(DMD) gene has 79 exons spanning at least 2,300 kb(2.3 Mb). The C terminus of the dystrophin protein is encoded by a highly conserved, alternatively spliced region of the gene. beta-dystroglycan binding activity is expressed by the dystrophin fragment spanning amino acids 3026-3345 containing the ZZ domain. DMD transcript is formed by at least 60 exons; the first half of the transcript is formed by a minimum of 33 exons spanning nearly 1000 kb, and the remaining portion has at least 27 exons that may spread over a similar distance. Dystrophin gene is expressed at a higher level in primary cultures of neuronal cells than in astro-glial cells derived from adult mouse brain. overexpression of dystrophin prevents the development of the abnormal mechanical properties associated with dystrophic muscle without causing deleterious side effects.
Immunogen: Recombinant human dystrophin fragment was used as the immunogen for this Dystrophin antibody.
Storage: After reconstitution, the Dystrophin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.
