Dystroglycan Antibody / DAG | F54375-0.4ML

Dystroglycan Antibody / DAG | F54375-0.4ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Mouse

Application: IHC-P, WB

Buffer: N/A

Limitation: This DAG1 antibody is available for research use only.

Purity: Antigen affinity purified

Description: Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.

Immunogen: A portion of amino acids 718-747 from the human protein was used as the immunogen for the DAG1 antibody.

Storage: Aliquot the DAG1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.