DYRK2 Kinase Assay Kit | 78392

DYRK2 Kinase Assay Kit | 78392 | Gentaur US, UK & Europe Disrtribition

Category: Kinase/Assay Kit

Application: Study enzyme kinetics and screen small molecular inhibitors for drug discovery and high throughput (HTS) applications.

Background: DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2) is a serine/threonine kinase as well as a tyrosine kinase implicated in the control of cell proliferation, cell cycle progression, and cytoskeleton organization. DYRK2 has demonstrated tyrosine autophosphorylation activity. It is notably activated by ATM in response to DNA damage and phosphorylates serine 46 on tumor suppressor TP53, leading to apoptosis. Many other targets have been identified, including various ligases involved in ubiquitination and ubiquitin-dependent proteasomal degradation of proteins. The kinase indisputably plays a role in various types of cancer, although its exact function and mechanism of action in cancer cells remains somewhat elusive.

Description: The DYRK2 Kinase Assay Kit is designed to measure DYRK2 kinase activity for screening and profiling applications using Kinase-Glo^® MAX as a detection reagent. 

Product Type: Assay Kit

Shippement Condition: -80°C