Description
DYRK2 Antibody | F54682-0.4ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human, Mouse
Application: WB, IHC-P
Buffer: N/A
Limitation: This DYRK2 antibody is available for research use only.
Purity: Antigen affinity purified
Description: Role in the regulation of cellular growth and/or development. Regulates TP53 by phosphorylation on Ser-46 to induce apoptosis in response to DNA damage, functioning downstream of ATM. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates (By similarity).
Immunogen: A portion of amino acids 521-549 from the mouse protein was used as the immunogen for the DYRK2 antibody.
Storage: Aliquot the DYRK2 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
