Description
Drebrin 1 Antibody | V7712-20UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Format: Purified
Clone: DBN1/3393
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human
Application: IHC-P, WB
Buffer: N/A
Limitation: This Drebrin 1 antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: Drebrins (developmentally regulated brain proteins) are cytoplasmic proteins that bind F-actin in the brain and are involved in cell migration, extension of neuronal processes and plasticity of dendrites. There are three isoforms: two embryonic types (E1 and E2); and an adult type (A), generated by alternative RNA splicing from a single Drebrin gene. Drebrins are expressed mainly in brain neurons but are also found in skeletal muscle, heart, placenta, pancreas and kidney. Drebrin has been designated as a marker of the dendritic spine. Decreases in Drebrin levels in the brain have been been associated with Alzheimer s disease and Down syndrome.
Immunogen: A recombinant human partial protein (amino acids 150-281) was used as the immunogen for the Drebrin 1 antibody.
Storage: Store the Drebrin 1 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
