DOK3 Polyclonal Antibody | E-AB-52149

DOK3 Polyclonal Antibody | E-AB-52149 | Gentaur US, UK & Europe Disrtribition

Reactivity: Human

Host: Rabbit

Isotype: IgG

Application: WB, ELISA

Research Area: Cancer, Signal Transduction

Background: DOK3 gene maps to chromosome 5q35.3. Dok3 was tyrosine phosphorylated by Src family members Lck, Fyn, and Lyn. Immunoprecipitation studies showed that Dok3 bound inhibitors SHIP and Csk but did not bind RasGAP. Dok3 binding to SHIP occurred via the SH2 domain. Dok3 also bound Csk via the Csk SH2 domain with possible involvement of the Csk SH3 domain as well.DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function

Lead Time: 7~10 days

Concentration: 0.4 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Fusion protein of human DOK3

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification: Antigen affinity purification

Dilution: WB 1:500-1:2000, ELISA 1:1000-1:5000

Conjugation: Unconjugated

Calculated Molecular Weight: 53 kDa

Observed Molecular Weight: Refer to figures

Clonality: Polyclonal