DOG1 Antibody / TMEM16A / ANO1 | V2315IHC-7ML

DOG1 Antibody / TMEM16A / ANO1 | V2315IHC-7ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*

Format: Purified

Clone: DG1/447

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: IHC-P

Buffer: N/A

Limitation: This TMEM16A antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: Expression of TMEM16A (DOG1) protein is elevated in the gastrointestinal stromal tumors (GIST's), c-kit signaling-driven mesenchymal tumors of the GI tract. It is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for TMEM16A has been reported in 97.8 percent of scorable GIST's, including all c-kit negative GIST's. Overexpression has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha (PDGFR alpha) mutants that fail to express c-kit antigen. The overall sensitivity of TMEM16A and c-kit in GIST's is nearly identical: 94.4% vs. 94.7%.

Immunogen: Recombinant human TMEM16A/DOG1 protein was used as the immunogen for this TMEM16A antibody.

Storage: Store the TMEM16A antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).