Dnmt1 Antibody | F53105-0.4ML

Dnmt1 Antibody | F53105-0.4ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Mouse

Application: WB, ELISA

Buffer: N/A

Limitation: This Dnmt1 antibody is available for research use only.

Purity: Antigen affinity

Description: Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. Three families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality.

Immunogen: A portion of amino acids 881-914 from the mouse protein was used as the immungen for the Dnmt1 antibody.

Storage: Aliquot the Dnmt1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.