Dnmt1 Antibody | F52797-0.08ML

Dnmt1 Antibody | F52797-0.08ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human

Application: WB, ELISA

Buffer: N/A

Limitation: This Dnmt1 antibody is available for research use only.

Purity: Antigen affinity

Description: Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. [UniProt]

Immunogen: This Dnmt1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 363-396 amino acids from the N-terminal region of the human protein.

Storage: Aliquot the Dnmt1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.