Description
DKK1 Antibody | F53121-0.08ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human, Mouse
Application: WB, ELISA
Buffer: N/A
Limitation: This DKK1 antibody is available for research use only.
Purity: Antigen affinity
Description: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. [UniProt]
Immunogen: This DKK1 antibody was produced from a rabbit immunized with a recombinant protein of human DKK1.
Storage: Aliquot the DKK1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
