DKK1 Antibody | F53121-0.08ML

DKK1 Antibody | F53121-0.08ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Mouse

Application: WB, ELISA

Buffer: N/A

Limitation: This DKK1 antibody is available for research use only.

Purity: Antigen affinity

Description: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. [UniProt]

Immunogen: This DKK1 antibody was produced from a rabbit immunized with a recombinant protein of human DKK1.

Storage: Aliquot the DKK1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.