Desmoglein 1 Antibody / DSG1 | V7720-20UG

Desmoglein 1 Antibody / DSG1 | V7720-20UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: 32-2B

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: IHC-P

Buffer: N/A

Limitation: This Desmoglein 1 antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: Desmoglein-1 is a member of the desmosomal cadherin family.Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms.Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.

Immunogen: Bovine desmoglein (desmosomal glyco protein I) from nasal epidermis was used as the immunogen for the Desmoglein 1 antibody.

Storage: Store the Desmoglein 1 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).