Description
Desmoglein 1 Antibody / DSG1 | V3265SAF-100UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 1 mg/ml in 1X PBS; BSA free, sodium azide free
Format: Purified
Clone: 27B2
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human
Application: FACS, IF, WB
Buffer: N/A
Limitation: This DSG1 antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: Desmoglein 1 (DSG1) is a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms. Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.
Immunogen: A recombinant protein corresponding to the intracellular domain of human Desmoglein 1 was used as the immunogen for the DSG1 antibody.
Storage: Store the DSG1 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
