Description
DERL1 Antibody / Derlin 1 | F54998-0.08ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human, Mouse
Application: FACS, IHC-P, WB
Buffer: N/A
Limitation: This Derlin 1 antibody is available for research use only.
Purity: Antigen affinity purified
Description: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. DERL1 may act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. It may mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.
Immunogen: A portion of amino acids 224-251 from the human protein was used as the immunogen for the Derlin 1 antibody.
Storage: Aliquot the Derlin 1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
