Description
DDR2 Antibody (TYRO10) | F50688-0.4ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: WB, IHC, FACS, ELISA
Buffer: N/A
Limitation: This DDR2 antibody is available for research use only.
Purity: Purified
Description: DDR2/TYRO10 is a tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. [UniProt]
Immunogen: This DDR2 antibody was produced from rabbits immunized with a his tag recombinant protein of human DDR2/TYRO10.
Storage: Aliquot the DDR2 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
