DCK Antibody / Deoxycytidine kinase | F54908-0.4ML

DCK Antibody / Deoxycytidine kinase | F54908-0.4ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Mouse

Application: WB, IF, IHC-P

Buffer: N/A

Limitation: This Deoxycytidine kinase antibody is available for research use only.

Purity: Purified

Description: Deoxycytidine kinase is responsible for the phosphorylation of several deoxyribonucleosides and their analogs. Deficiency of this enzyme activity is associated with resistance to antiviral and anticancer chemotherapeutic agents, whereas increased enzyme activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. It is the rate limiting enzyme in the activation of many important anticancer and retroviral drugs and its activity is often decreased in cells that are resistant to cytosine arabinoside.

Immunogen: A portion of amino acids 171-200 from the human protein was used as the immunogen for the Deoxycytidine kinase antibody.

Storage: Aliquot the Deoxycytidine kinase antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.