DCAMKL1, GST-tag | 40047

DCAMKL1, GST-tag | 40047 | Gentaur US, UK & Europe Disrtribition

Category: Kinase-Serine/Threonine/Protein

Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling

Background: DCAMKL1 or doublecortin-like kinase 1 contains two N-terminal doublecortin domains (which bind microtubules and regulate microtubule polymerization), a C-terminal serine/threonine protein kinase domain (which shows substantial homology to Ca2+/calmodulin-dependent protein kinase), and a serine/proline-rich domain in between the doublecortin and the protein kinase domains (which mediates multiple protein-protein interactions) (1). DCAMKL1 is a microtubule-associated kinase that can undergo autophosphorylation. DCAMKL1 has microtubule-polymerizing activity that is independent of its protein kinase activity (2). DCAMKL1 is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis.

Description: Recombinant human DCAMKL1, also known as DCLK1, DCDC3A, DCLK, or KIAA0369, GenBank Accession No. NM_004734, full-length with an N-terminal GST tag and expressed in a baculovirus-infected Sf9 cell expression system.

Product Type: Protein

Shippement Condition: -80°C