Cytokeratin 8/18 Antibody Cocktail | V3068-100UG

Cytokeratin 8/18 Antibody Cocktail | V3068-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Format: Purified

Clone: KRT8/803 + KRT18/835

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: IHC-P

Buffer: N/A

Limitation: This Cytokeratin 8/18 antibody cocktail is available for research use only.

Purity: Protein G affinity chromatography

Description: Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). This mAb cocktail recognizes all simple epithelia including glandular epithelium, for example thyroid, female breast, gastrointestinal tract, respiratory tract, and urogenital tract including transitional epithelium. All adenocarcinomas and most squamous carcinomas are positive but keratinizing squamous carcinomas are usually negative. This antibody is useful in demonstrating the presence of Paget cells; there is very little keratin 18 in the normal epidermis so only Paget cells are stained. Immuno-histochemical staining with this mAb is indistinguishable from that obtained with monoclonal antibody 5D3.

Immunogen: Recombinant full-length human KRT8 protein (KRT8/803) and KRT18 protein (KRT18/835) were used as the immunogen for the Cytokeratin 8/18 antibody cocktail.

Storage: Store the Cytokeratin 8/18 antibody cocktail at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).