Description
Cytokeratin 14 Antibody / CK14 / KRT14 | V2175BTN | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.1 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Format: Biotin Conjugate
Clone: LL002
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human, Mouse and Rat
Application: FACS, IF, IHC-P
Buffer: N/A
Limitation: This Cytokeratin 14 antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: Cytokeratin 14 (CK14) belongs to the type I (or A or acidic) subfamily of low molecular weight keratins and exists in combination with keratin 5 (type II or B or basic). CK14 is found in basal cells of squamous epithelia, some glandular epithelia, myoepithelium, and mesothelial cells. Anti-CK14 is useful in differentiating squamous cell carcinomas from poorly differentiated epithelial tumors. Anti-CK14 is one of the specific basal markers for distinguishing between basal and non-basal subtypes of breast carcinomas. Anti-CK14 is also a good marker for differentiation of intraductal from invasive salivary duct carcinoma by the positive staining of basal cells surrounding the in-situ neoplasm as well as for differentiation of benign prostate from prostate carcinoma. Furthermore, this antibody has been useful in separating oncocytic tumors of the kidney from its renal mimics, and in identifying metaplastic carcinomas of the breast.
Immunogen: A synthetic peptide of 15 amino acid from the C-terminus of the human protein was used as the immunogen for the Cytokeratin 14 antibody.
Storage: Store the Cytokeratin 14 antibody at 2-8oC (up to one month) or aliquot and store at -20 °C (longer term).
