CYP27B1 Antibody | F54519-0.2ML

CYP27B1 Antibody | F54519-0.2ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Rat

Application: WB, IHC-P, FACS

Buffer: N/A

Limitation: This CYP27B1 antibody is available for research use only.

Purity: Antigen affinity purified

Description: CYP27B1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.

Immunogen: A portion of amino acids 482-508 from the human protein was used as the immunogen for the CYP27B1 antibody.

Storage: Aliquot the CYP27B1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.