Description
Cynomolgus TSLP Protein, His Tag | TSP-C52H8-1mg| Gentaur Distribution US, UK & Europe
Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine involved in the pathology of inflammatory skin diseases, and is widely expressed by epithelial cells. Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence (4, 5). Human TSLP has been shown to developing nondeletional central tolerance, amplifying epithelium-induced class switching, inducing atopic diseases and maintaining intestinal noninflammatory environment. Among diverse cells responding to Human TSLP, CD11c+ dendritic cells are the most obviously characterized target cells.
Source: Cynomolgus TSLP, His Tag (TSP-C52H8) is expressed from human 293 cells (HEK293). It contains AA Tyr 29 - Gln 159 (Accession # A0A7N9CAT7-1).
Format: Powder.
Tag: C-10×His.
Expression System: HEK293.
Expression Region: Tyr 29 - Gln 159.
Conjugate: Unconjugated.
Molecular Weight: 11.7 kDa and 5.4 kDa.
Characteristics: This protein carries a polyhistidine tag at the C-terminus. This protein contains a furin convertase cleavage site, 127-RRKR-130, and will be processed into N and C-terminal fragment with calculated MW of 11.7 kDa and 5.4 kDa respectively. The protein migrates as 21 kDa, 15 kDa and 8 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 90%.
Buffer: PBS, pH7.4.
Storage Conditions: -20℃.
Shipping Conditions: RT
