Cynomolgus Siglec-15 / CD33L3 Protein, Fc Tag | SG5-C5253-1mg

Cynomolgus Siglec-15 / CD33L3 Protein, Fc Tag | SG5-C5253-1mg| Gentaur Distribution US, UK & Europe

Siglec-15 is a DAP12-associated immunoreceptor, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Siglecs are cell surface proteins that bind sialic acid. They are found primarily on the surface of immune cells and are a subset of the I-type lectins. Siglec-15 consisting of immunoglobulin (Ig) -like domains, transmembrane domain and a short cytoplasmic tail. Siglec-15 is that recognizes sialylated glycans and regulates osteoclast differentiation. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.

Source: Cynomolgus Siglec-15, Fc Tag (SG5-C5253) is expressed from human 293 cells (HEK293). It contains AA Phe 20 - Thr 263 (Accession # A0A2K5UY47-1).

Format: Powder.

Tag: C-Fc.

Expression System: HEK293.

Expression Region: Phe 20 - Thr 263.

Conjugate: Unconjugated.

Molecular Weight: 52.7 kDa.

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 52.7 kDa. The protein migrates as 60-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: 50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5.

Storage Conditions: -20℃.

Shipping Conditions: RT