Description
Cynomolgus / Rhesus macaque Fas Ligand / TNFSF6 Protein, His Tag, premium grade | FAL-H5246-50ug| Gentaur Distribution US, UK & Europe
Fas ligand is also known as FasL, CD178, CD95L, or TNFSF6, is a homotrimeric type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer. Mature human Fas Ligand consists of a 179 amino acid (aa) extracellular domain (ECD), a 22 aa transmembrane segment, and a 80 aa cytoplasmic domain. Within the ECD, human Fas Ligand shares 81% and 78% aa sequence identity with mouse and rat Fas Ligand, respectively. Apoptosis triggered by Fas-Fas ligand binding plays a fundamental role in the regulation of the immune system. Its functions include:T-cell homeostasis, cytotoxic T-cell activity, immune privilege, maternal tolerance, tumor counterattack. Defective Fas-mediated apoptosis may lead to oncogenesis as well as drug resistance in existing tumors. Germline mutation of Fas is associated with autoimmune lymphoproliferative syndrome (ALPS), a childhood disorder of apoptosis.
Source: Cynomolgus / Rhesus macaque Fas Ligand Protein, His Tag, premium grade (FAL-H5246) is expressed from human 293 cells (HEK293). It contains AA Pro 133 - Leu 280 (Accession # P63308-1).
Format: Powder.
Tag: N-10×His.
Expression System: HEK293.
Expression Region: Pro 133 - Leu 280.
Conjugate: Unconjugated.
Molecular Weight: 18.8 kDa.
Characteristics: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 18.8 kDa. The protein migrates as 27-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 90%.
Buffer: PBS, pH7.4.
Storage Conditions: -20℃.
Shipping Conditions: RT
