Cynomolgus Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein, His Tag&Tag Free | IT5-C52W3-100ug

Cynomolgus Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein, His Tag&Tag Free | IT5-C52W3-100ug| Gentaur Distribution US, UK & Europe

Integrin alpha V beta 5 (ITGAV & ITGB5) is expressed on a wide variety of cell types including keratinocytes, fibroblasts, adhesive monocytes, embryonic stem cells, and select endothelium and epithelium. ITGAV & ITGB5 binds ligands containing an RGD motif, notably vitronectin. Growth factors that increase PKC activity, such as VEGF or TGF alpha, promote ITGAV & ITGB5-mediated angiogenesis while alpha V beta 3, which may be expressed in the same cell, responds to FGF-basic and TNF alpha. An inhibitor of both down regulates tumor angiogenesis. During lung inflammation, up regulation of ITGAV & ITGB5 on myofibroblasts or infiltrating lymphocytes may contribute to fibrosis by freeing TGF beta from latency.

Source: Cynomolgus Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein, His Tag&Tag Free (IT5-C52W3) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Pro 993 & Leu 25 - Asn 719 (Accession # A0A2K5WCD3-1 & A0A2K5UEB4).

Format: Powder.

Tag: C-10×His | Native.

Expression System: HEK293.

Expression Region: Phe 31 - Pro 993 & Leu 25 - Asn 719.

Conjugate: Unconjugated.

Molecular Weight: 113.1 kDa & 81.8 kDa.

Characteristics: Cynomolgus Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAV and ITGB5, has a calculated MW of 113.1 kDa (ITGAV) and 81.8 kDa (ITGB5). The protein migrates as 80-90 kDa, 120-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

Purity: 90%.

Buffer: 50 mM Tris, 150 mM NaCl, PH 7.5.

Storage Conditions: -20℃.

Shipping Conditions: RT