Cynomolgus IL-2 R alpha / CD25 Protein, His Tag (MALS verified) | ILA-C52H8-1mg

Cynomolgus IL-2 R alpha / CD25 Protein, His Tag (MALS verified) | ILA-C52H8-1mg| Gentaur Distribution US, UK & Europe

Interleukin-2 receptor subunit alpha (IL2RA) is also known as IL-2R subunit alpha, IL-2-RA, IL2-RA, TAC antigen, p55, CD antigen CD25, is a type I transmembrane glycoprotein. IL2RA is expressed on activated T cells and regulatory T cells, and is capable of binding IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covelently with the IL2 receptor beta and gamma chain, and subsequently initiates the intacellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been previously regarded as an activation marker, while both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling.

Source: Cynomolgus IL-2 R alpha Protein, His Tag (ILA-C52H8) is expressed from human 293 cells (HEK293). It contains AA Glu 22 - Glu 238 (Accession # H6WS54).

Format: Powder.

Tag: C-10×His.

Expression System: HEK293.

Expression Region: Glu 22 - Glu 238.

Conjugate: Unconjugated.

Molecular Weight: 26.3 kDa.

Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.3 kDa. The protein migrates as 52-57 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 90%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT