Description
Cynomolgus IL-17A / CTLA-8 Protein, His Tag (MALS verified) | ILA-C5249-1mg| Gentaur Distribution US, UK & Europe
Interleukin-17A (IL17A) is also known as cytotoxic T-lymphocyte-associated antigen 8 (CTLA8), which is a proinflammatory cytokine produced by activated T cells. IL17A can regulate the activities of NF-kappaB and mitogen-activated protein kinases. Also, IL17A can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).Furthermore, IL17A has been found both in glycosylated and nonglycosylated forms. High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Source: Cynomolgus IL-17A, His Tag (ILA-C5249) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Ala 155 (Accession # XP_005552816.1).
Format: Powder.
Tag: N-10×His.
Expression System: HEK293.
Expression Region: Gly 24 - Ala 155.
Conjugate: Unconjugated.
Molecular Weight: 17.0 kDa.
Characteristics: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 17.0 kDa. The protein migrates as 18-19 kDa, 24-25 kDa and 28-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 90%.
Buffer: PBS, pH7.4.
Storage Conditions: -20℃.
Shipping Conditions: RT
