Cynomolgus IL-13 Protein, His Tag (MALS verified) | IL3-C5249-500ug

Cynomolgus IL-13 Protein, His Tag (MALS verified) | IL3-C5249-500ug| Gentaur Distribution US, UK & Europe

Interleukin 13 (IL13) is also known as ALRH, BHR1and P600, is a single-chain glycosylated polypeptide, and is a cytokine critical in regulating inflammatory and immune responses. IL13 is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains. The functions of IL-13 overlap considerably with those of IL-4, especially with regard to changes induced on hematopoietic cells, but these effects are probably less important given the more potent role of IL-4. IL-13 induces matrix metalloproteinases (MMPs) as part of a mechanism that protects against excessive allergic inflammation that predisposes to asphyxiation. IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, which all contribute to airway obstruction.

Source: Cynomolgus IL-13, His Tag (IL3-C5249) is expressed from human 293 cells (HEK293). It contains AA Ser 21 - Asn 132 (Accession # ABG75889.1).

Format: Powder.

Tag: N-10×His.

Expression System: HEK293.

Expression Region: Ser 21 - Asn 132.

Conjugate: Unconjugated.

Molecular Weight: 14.2 kDa.

Characteristics: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 14.2 kDa. The protein migrates as 29-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 90%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT